N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide

Base Information

• Chemical Name: N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide
• CAS No.: 677718-62-6
• Molecular Formula: C₃₆H₄₇N₃O₅
• Molecular Weight: 601.786
• Mol file: 677718-62-6.mol

Synonyms:N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide

Chemical Property of N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide

There total 4 articles about N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,5-dioxopyrrolidinyl 3-(N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}carbamoyl)propanoate (677718-42-2) + N-(8-aminooctyl)benzamide (66095-35-0) → N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide (677718-62-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.200601036

Reference yield:

3-(N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}carbamoyl)propanoic acid (677718-39-7) → N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide (677718-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / triethylamine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / tetrahydrofuran / Heating

2: 77 percent / triethylamine / tetrahydrofuran / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran;

DOI:10.1002/ejoc.200601036

Reference yield:

1,3-bis(benzyloxy)propan-2-amine (132819-08-0) → N'-[8-(phenylcarbonylamino)octyl]-N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}butane-1,4-diamide (677718-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / pyridine / 4 h / 100 °C

2: 74 percent / triethylamine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / tetrahydrofuran / Heating

3: 77 percent / triethylamine / tetrahydrofuran / 20 °C

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran;

DOI:10.1002/ejoc.200601036

upstream raw materials:

2,5-dioxopyrrolidinyl 3-(N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}carbamoyl)propanoate

N-(8-aminooctyl)benzamide

3-(N-{2-(phenylmethoxy)-1-[(phenylmethoxy)methyl]ethyl}carbamoyl)propanoic acid

1,3-bis(benzyloxy)propan-2-amine