1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate
CAS No.:1004755-28-5
Molecular Formula:C₃₁H₃₄Cl₂N₂O₄
Molecular Weight:569.528
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

There total 1 articles about 1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1004755-02-5,1149765-08-1
1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

: C₃₁H₃₄Cl₂N₂O₄

: 1004755-28-5
1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

Guidance literature:: 1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate; With n-butyllithium; diisopropylamine; 1,10-Phenanthroline; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.13333h;

3-phenyl-propionaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 2.16667h; Product distribution / selectivity;

Reference yield: 72.0%

: 1004755-28-5
1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

: 1004755-29-6
(3S)-hydroxy-5-phenyl-(2R)-[((1'R)-phenylethyl)amino]pentanoic acid

Guidance literature:: 1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate; With hydrogenchloride; water; at 120 - 130 ℃; for 4h;

With sodium hydroxide; water; at 0 ℃; for 1h; pH=7.2;

Reference yield:

: 1004755-28-5
1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate

: 1004755-33-2
(2R,3S)-2-amino-3-hydroxy-5-phenylpentanoic acid hydrochloride

Guidance literature:: 1,1-dimethylethyl (2S)-(2,6-dichlorophenyl)-(4R)-((1S)-hydroxy-3-phenylpropyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate; With hydrogenchloride; hydrogen; palladium hydroxide on carbon; In tetrahydrofuran; water; at 40 ℃; for 42h; under 16501.7 Torr;

With hydrogenchloride; water; at 120 - 130 ℃; for 4h;