3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal

Base Information

• Chemical Name: 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal
• CAS No.: 122223-46-5
• Molecular Formula: C₂₁H₁₈FNO
• Molecular Weight: 319.378
• Mol file: 122223-46-5.mol

Synonyms:3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal

Chemical Property of 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal

There total 7 articles about 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluorophenyl)-2-nitropropene (134538-46-8,775-31-5) → 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal (122223-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 26.0 g / ethanol / 30 h / Heating

2: 1.) lithium aluminum hydride / 1.) ether, 0 deg C, 1 h, 2.) RT, 2 h

3: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In diethyl ether; ethanol;

DOI:10.1021/jm00163a011

Reference yield:

1-phenyl-2,5-dimethyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole (122223-44-3) → 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal (122223-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; triethylamine; In diethyl ether;

DOI:10.1021/jm00163a011

Reference yield:

ethyl 1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxylate (122223-43-2) → 3-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>-(E)-propenal (122223-46-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) lithium aluminum hydride / 1.) ether, 0 deg C, 1 h, 2.) RT, 2 h

2: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In diethyl ether;

DOI:10.1021/jm00163a011

upstream raw materials:

1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde

tributyl(2-ethoxyvinyl)stannane

1-(4-fluorophenyl)-2-nitropropene

1-phenyl-2,5-dimethyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

Downstream raw materials:

methyl 5(RS)-hydroxy-3-oxo-7-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

methyl 3(RS),5(SR)-dihydroxy-7-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

methyl 3(RS),5(RS)-dihydroxy-7-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

methyl 3(RS),5(SR)-dihydroxy-7-<1-phenyl-2,5-dimethyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate