2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Chemical Name:2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester
CAS No.:361535-25-3
Molecular Formula:C₁₉H₂₀N₂O₅S
Molecular Weight:388.444
Hs Code.:

Synonyms:2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

There total 4 articles about 2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98-59-9
p-toluenesulfonyl chloride

: 161468-45-7
tert‐butyl 2‐oxo‐2,3‐dihydro‐1H‐benzo[d]imidazole‐1‐carboxylate

: 361535-25-3
2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1515/znb-2002-0315

Reference yield:

: 615-16-7
1,3-dihydro-2H-benzimidazol-2-one

: 361535-25-3
2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 68 percent / dimethylformamide / 24 h / 20 °C

2.1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 20 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1515/znb-2002-0315

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 361535-25-3
2,3-dihydro-2-oxo-3-(4-tolylsulfonyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 68 percent / dimethylformamide / 24 h / 20 °C

2.1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 20 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1515/znb-2002-0315