1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid

Base Information

• Chemical Name: 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid
• CAS No.: 195503-66-3
• Molecular Formula: C₁₉H₂₆N₂O₅
• Molecular Weight: 362.426
• Mol file: 195503-66-3.mol

Synonyms:1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid

Chemical Property of 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid

There total 3 articles about 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

{1-Methyl-1-[1-(methyl-phenyl-carbamoyl)-cyclohexylcarbamoyl]-ethyl}-carbamic acid benzyl ester (195503-65-2) → 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid (195503-66-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 0 ℃; for 4h;

DOI:10.1002/hlca.19970800515

Reference yield:

Z-Aib-OH (15030-72-5) → 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid (195503-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / CH₂Cl₂ / 16 h / Ambient temperature

2: 86 percent / 6N HCl / tetrahydrofuran / 4 h / 0 °C

With hydrogenchloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/hlca.19970800515

Reference yield:

3-(N-methyl-N-phenylamino)-2,2-pentamethylen-2H-azirin (112142-87-7) → 1-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-cyclohexanecarboxylic acid (195503-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / CH₂Cl₂ / 16 h / Ambient temperature

2: 86 percent / 6N HCl / tetrahydrofuran / 4 h / 0 °C

With hydrogenchloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/hlca.19970800515

upstream raw materials:

{1-Methyl-1-[1-(methyl-phenyl-carbamoyl)-cyclohexylcarbamoyl]-ethyl}-carbamic acid benzyl ester

Z-Aib-OH

3-(N-methyl-N-phenylamino)-2,2-pentamethylen-2H-azirin