(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

Base Information

Chemical Name:(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt
CAS No.:103531-46-0
Molecular Formula:C₂₆H₂₆FN₃O₅
Molecular Weight:479.508
Hs Code.:

(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

Synonyms:(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

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Chemical Property of (+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

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MSDS Files:: SDS file from LookChem

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Technology Process of (+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

There total 7 articles about (+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 120-43-4
4-ethoxycarbonylpiperazine

: 103531-44-8
(-)-7-chloro-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 103531-46-0
(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

Guidance literature:: In various solvent(s); at 100 - 110 ℃; for 18h;
DOI:10.1021/jm00160a042

Reference yield:

: 95-62-5,155-09-9,3721-26-4,3721-28-6,13531-35-6,24873-95-8,69684-88-4,69684-89-5,54-97-7
(1R,2S)-1-amino-2-phenylcyclopropane

: 103531-46-0
(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.5 h / Ambient temperature

2: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C

3: 87 percent / KOH / tetrahydrofuran; H₂O / 1.5 h / 65 - 70 °C

4: 90 percent / various solvent(s) / 18 h / 100 - 110 °C

With potassium hydroxide; sodium hydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00160a042

Reference yield:

: 155-09-9
trans-2-phenylcyclopropylamine

: 103531-46-0
(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

Guidance literature:: Multi-step reaction with 5 steps

2: CH₂Cl₂ / 0.5 h / Ambient temperature

3: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C

4: 87 percent / KOH / tetrahydrofuran; H₂O / 1.5 h / 65 - 70 °C

5: 90 percent / various solvent(s) / 18 h / 100 - 110 °C

With potassium hydroxide; sodium hydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00160a042