Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

Base Information

Chemical Name:Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester
CAS No.:193018-50-7
Molecular Formula:C₁₇H₂₃NO₇
Molecular Weight:353.372
Hs Code.:

Synonyms:Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

Suppliers and Price of Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

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Technology Process of Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

There total 5 articles about Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 151-50-8
potassium cyanide

: 193018-44-9
Acetic acid (R)-3-methanesulfonyloxy-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

: 193018-50-7
Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

Guidance literature:: With 18-crown-6 ether; In dimethyl sulfoxide;
DOI:10.1055/s-1997-3266

Reference yield:

: 2-Iodo-5-methoxy-1,3-bis-methoxymethoxy-benzene

: 193018-50-7
Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OAc)2, Ph₃P, iPr₂NEt / dimethylformamide

2: 1.) O₃; 2.) NaBH₄ / 2.) MeOH

3: diethyl ether / Ambient temperature; lipase AL originated from Achromobacter sp.

4: 89 percent / iPr₂NEt, 4-DMAP / CH₂Cl₂

5: 72 percent / 18-crown-6 / dimethylsulfoxide

With dmap; palladium diacetate; sodium tetrahydroborate; 18-crown-6 ether; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-3266

Reference yield:

: 193018-45-0
2-(4-Methoxy-2,6-bis-methoxymethoxy-phenyl)-propane-1,3-diol

: 193018-50-7
Acetic acid (R)-3-cyano-2-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / Ambient temperature; lipase AL originated from Achromobacter sp.

2: 89 percent / iPr₂NEt, 4-DMAP / CH₂Cl₂

3: 72 percent / 18-crown-6 / dimethylsulfoxide

With dmap; 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1055/s-1997-3266