12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester

Base Information

• Chemical Name: 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester
• CAS No.: 753498-18-9
• Molecular Formula: C₅₁H₇₈N₂O₆Si
• Molecular Weight: 843.276
• Mol file: 753498-18-9.mol

Synonyms:12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester

Chemical Property of 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester

There total 7 articles about 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

12-(3,5-di-tert-butylphenoxy)dodecanoic acid (503310-23-4) + N-{[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-ethylcarbamoyl]-methyl}-2,2-diphenyl-acetamide (753498-17-8) → 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester (753498-18-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 14h;

DOI:10.1002/anie.200353606

Reference yield:

methyl 12-bromododecanoate (26825-95-6) → 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester (753498-18-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃; NaI / butan-2-one / 48 h / Heating

2: 98 percent / aq. NaOH / 16 h / Heating

3: 87 percent / EDCI; 4-DMAP / 14 h / 20 °C

With dmap; sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In butanone;

DOI:10.1002/anie.200353606

Reference yield:

3,5-Di-tert-butylphenol (1138-52-9) → 12-(3,5-di-tert-butyl-phenoxy)-dodecanoic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(2-diphenylacetylamino-acetylamino)-propyl ester (753498-18-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃; NaI / butan-2-one / 48 h / Heating

2: 98 percent / aq. NaOH / 16 h / Heating

3: 87 percent / EDCI; 4-DMAP / 14 h / 20 °C

With dmap; sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In butanone;

DOI:10.1002/anie.200353606

upstream raw materials:

12-(3,5-di-tert-butylphenoxy)dodecanoic acid

N-{[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-ethylcarbamoyl]-methyl}-2,2-diphenyl-acetamide

methyl 12-bromododecanoate

3,5-Di-tert-butylphenol