(+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

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Chemical Name:(+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal
CAS No.:596812-45-2
Molecular Formula:C₃₁H₄₀O₃Si
Molecular Weight:488.742
Hs Code.:

Synonyms:(+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

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Chemical Property of (+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

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Technology Process of (+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

There total 4 articles about (+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 596812-58-7
2-{(2R,6S)-6-[(1E,4E)-6-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-hexa-1,4-dienyl]-4-methylene-tetrahydro-pyran-2-yl}-ethanol

: 596812-45-2
(+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

Guidance literature:: With phthalic acid dimethyl ester; In dichloromethane;
DOI:10.1021/ja035579q

Reference yield:

: (2E,5E)-7-{[(1,1-dimethylethyl)diphenylsilyl]oxy}-3-methyl-2,5-heptadienal

: 596812-45-2
(+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / camphorsulfonic acid / diethyl ether

2: 80 percent / DIBALH / CH₂Cl₂

3: 82 percent / DMP / CH₂Cl₂

With phthalic acid dimethyl ester; camphor-10-sulfonic acid; diisobutylaluminium hydride; In diethyl ether; dichloromethane; 3: Dess-Martin oxidation;
DOI:10.1021/ja035579q

Reference yield:

: (-)-(3S)-5-{[(trimethylsilyl)methyl]-3-[(trimethysilyl)oxy]hex-5-enyl}-2,2-dimethylpropanoate

: 596812-45-2
(+)-2-[(2R,6S)-6-[(1E,4E)-6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-1,4-hexadienyl]tetrahydro-4-methylene-2H-pyran-2-yl]ethanal

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / camphorsulfonic acid / diethyl ether

2: 80 percent / DIBALH / CH₂Cl₂

3: 82 percent / DMP / CH₂Cl₂

With phthalic acid dimethyl ester; camphor-10-sulfonic acid; diisobutylaluminium hydride; In diethyl ether; dichloromethane; 3: Dess-Martin oxidation;
DOI:10.1021/ja035579q