(2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS No.:1448187-37-8
Molecular Formula:C₂₃H₃₂N₄O₄S
Molecular Weight:460.597
Hs Code.:

Synonyms:(2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Chemical Property of (2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Technology Process of (2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

There total 10 articles about (2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1448187-33-4
(2S,4R)-4-hydroxy-1-((S)-2-(methylamino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

: 6482-24-2
2-Bromoethyl methyl ether

: 1448187-37-8
(2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 85 ℃; for 18h;

Reference yield:

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 1448187-37-8
(2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h

2.1: hydrogenchloride / dichloromethane; methanol; 1,4-dioxane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 85 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: (2S,4R)-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride

: 1448187-37-8
(2S,4R)-4-hydroxy-1-((S)-2-((2-methoxyethyl)(methyl)amino)propanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 85 °C

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;