(4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol

Base Information

• Chemical Name: (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol
• CAS No.: 234766-60-0
• Molecular Formula: C₄₈H₇₆O₄Si₅
• Molecular Weight: 857.557
• Mol file: 234766-60-0.mol

Synonyms:(4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol

Chemical Property of (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol

There total 3 articles about (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C72H132O4Si9 (234766-59-7) → (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol (234766-60-0)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; for 17h;

DOI:10.1002/(SICI)1521-3773(19990601)38:11<1655::AID-ANIE1655>3.0.CO;2-2

Reference yield:

4-(tert-butyldimethylsiloxymethyl)bromobenzene (87736-74-1) → (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol (234766-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuLi / diethyl ether; pentane / -78 - -20 °C

1.2: 89 percent / diethyl ether; pentane / 20 °C

2.1: 74 percent / Et₃N*3HF / tetrahydrofuran / 20 °C

With tert.-butyl lithium; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; diethyl ether; pentane; 1.1: Metallation / 1.2: Substitution / 2.1: desilylation;

DOI:10.1021/jo991726k

Reference yield:

tetra[3-(dimethylchlorosilyl)propyl]silane (161638-89-7) → (4-{dimethyl-[3-(tris-{3-[(4-hydroxymethyl-phenyl)-dimethyl-silanyl]-propyl}-silanyl)-propyl]-silanyl}-phenyl)-methanol (234766-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuLi / diethyl ether; pentane / -78 - -20 °C

1.2: 89 percent / diethyl ether; pentane / 20 °C

2.1: 74 percent / Et₃N*3HF / tetrahydrofuran / 20 °C

With tert.-butyl lithium; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; diethyl ether; pentane; 1.1: Metallation / 1.2: Substitution / 2.1: desilylation;

DOI:10.1021/jo991726k

upstream raw materials:

C₇₂H₁₃₂O₄Si₉

4-(tert-butyldimethylsiloxymethyl)bromobenzene

tetra[3-(dimethylchlorosilyl)propyl]silane

Downstream raw materials:

phenyl-acetic acid 4-{dimethyl-[3-(tris-{3-[dimethyl-(4-phenylacetoxymethyl-phenyl)-silanyl]-propyl}-silanyl)-propyl]-silanyl}-benzyl ester