11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide

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Chemical Name:11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide
CAS No.:910295-53-3
Molecular Formula:C₄₇H₅₆F₂N₄O₄
Molecular Weight:778.983
Hs Code.:

Synonyms:11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide

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Chemical Property of 11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide

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Technology Process of 11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide

There total 3 articles about 11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 4403-42-3
11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid

: 616875-76-4
4-[3-(4-{2-[bis-(4-fluoro-phenyl)methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenylamine

: 910295-53-3
11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.097

Reference yield:

: 4403-42-3
11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid

: 910295-53-3
11-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-undecanoic acid {4-[3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / CH₂Cl₂

2: CH₂Cl₂

With thionyl chloride; In dichloromethane;
DOI:10.1016/j.bmcl.2006.05.097