N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

Base Information

Chemical Name:N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide
CAS No.:903886-69-1
Molecular Formula:C₁₅H₁₅N₃O₂S
Molecular Weight:301.369
Hs Code.:

<i>N</i>-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

Synonyms:N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

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Chemical Property of N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

Chemical Property:

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Technology Process of N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

There total 3 articles about N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 903886-68-0
tert-butyl 4-({5-[3-(acetylamino)but-1-ynyl]-1,3-thiazol-2-yl}oxy)phenylcarbamate

: 903886-69-1
N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm060484v

Reference yield:

: 903886-67-9
[4-(5-bromothiazol-2-yloxy)phenyl]carbamic acid tert-butyl ester

: 903886-69-1
N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Et₃N; CuI; PdCl₂(PPh)2 / tetrahydrofuran / 0.5 h / 80 °C

2: TFA / CH₂Cl₂ / 4 h / 20 °C

With copper(l) iodide; PdCl₂(PPh)2; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;
DOI:10.1021/jm060484v

Reference yield:

: 54840-15-2
4-N-tert-butoxycarbonylaminophenol

: 903886-69-1
N-{3-[2-(4-amino-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / K₂CO₃ / dimethylsulfoxide / 3 h / 130 °C

2: 81 percent / Et₃N; CuI; PdCl₂(PPh)2 / tetrahydrofuran / 0.5 h / 80 °C

3: TFA / CH₂Cl₂ / 4 h / 20 °C

With copper(l) iodide; PdCl₂(PPh)2; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2: Sonogashira coupling;
DOI:10.1021/jm060484v