1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

Base Information

Chemical Name:1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde
CAS No.:166755-31-3
Molecular Formula:C₂₀H₂₃N₃O₄
Molecular Weight:369.42
Hs Code.:

Synonyms:1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

There total 5 articles about 1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36980-62-8
[(2Z)-2-cyano-3-ethoxybut-2-enoyl]aminocarboxylic acid ethyl ester

: 166755-31-3
1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 4 h / Heating

2: aq. NaOH / 18 h

3: 70percent aq. HCO₂H / RaNi / 0.25 h / 95 °C

4: Br₂ / CHCl₃ / 1 h / 50 °C

5: TEA / ethanol / Ambient temperature

6: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -60 deg C, 45 min, b) RT, 14 h

With sodium hydroxide; n-butyllithium; formic acid; TEA; bromine; RaNi; In ethanol; chloroform;
DOI:10.1021/jm00014a009

Reference yield:

: 133181-39-2
5-cyano-6-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione

: 166755-31-3
1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / 18 h

2: 70percent aq. HCO₂H / RaNi / 0.25 h / 95 °C

3: Br₂ / CHCl₃ / 1 h / 50 °C

4: TEA / ethanol / Ambient temperature

5: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -60 deg C, 45 min, b) RT, 14 h

With sodium hydroxide; n-butyllithium; formic acid; TEA; bromine; RaNi; In ethanol; chloroform;
DOI:10.1021/jm00014a009

Reference yield:

: 166754-96-7
5-cyano-3,6-dimethyl-1-(2-methylpropyl)pyrimidine-2,4-dione

: 166755-31-3
1-Isobutyl-6-(4-methoxy-benzyl)-3-methyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 70percent aq. HCO₂H / RaNi / 0.25 h / 95 °C

2: Br₂ / CHCl₃ / 1 h / 50 °C

3: TEA / ethanol / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -60 deg C, 45 min, b) RT, 14 h

With n-butyllithium; formic acid; TEA; bromine; RaNi; In ethanol; chloroform;
DOI:10.1021/jm00014a009