3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide

Base Information

• Chemical Name: 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide
• CAS No.: 935521-25-8
• Molecular Formula: C₁₈H₂₇NO₂Si
• Molecular Weight: 317.503
• Mol file: 935521-25-8.mol

Synonyms:3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide

Chemical Property of 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide

There total 1 articles about 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-ethynylbenzene (173074-01-6) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propynoic acid dimethylamide (935521-25-8)

Guidance literature:

1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-ethynylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -40 ℃; for 0.666667h;

N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; hexane; at -40 - 20 ℃; for 0.666667h;

DOI:10.1016/j.tet.2007.01.046

upstream raw materials:

1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-ethynylbenzene

N,N-Dimethylcarbamoyl chloride