1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate
CAS No.:1140590-82-4
Molecular Formula:C₃₈H₄₉N₃O₈
Molecular Weight:675.822
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

There total 6 articles about 1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140590-81-3
Sodium Salt of 5-(benzyloxy)-2-({1-[(1,1-dimethylethoxy)carbonyl]-piperidin-4-yl}[(2-methylpropoxy)carbonyl]amino)benzoic acid

: 5763-61-1
3,4-dimethoxybenzylamine

: 1140590-82-4
1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

Guidance literature:: Sodium Salt of 5-(benzyloxy)-2-({1-[(1,1-dimethylethoxy)carbonyl]-piperidin-4-yl}[(2-methylpropoxy)carbonyl]amino)benzoic acid; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3,4-dimethoxybenzylamine; In N,N-dimethyl-formamide; at 20 ℃; for 448h;

Reference yield:

: 1140590-81-3
sodium salt of 5-(benzyloxy)-2-({1-[(1,1-dimethylethoxy)carbonyl]piperidin-4-yl}[(2-methylpropoxy)carbonyl]amino)benzoic acid

: 5763-61-1
3,4-dimethoxybenzylamine

: 1140590-82-4
1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

Guidance literature:: With DIEA; HBTU; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1140590-82-4
1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 110 °C / Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / 1,2-dichloro-ethane / 80 °C / Microwave irradiation

3.1: sodium hydroxide; water / methanol / 3 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 448 h / 20 °C

With water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;