3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1262106-29-5
Molecular Formula:C₂₄H₂₁F₃N₄O₂
Molecular Weight:454.452
Hs Code.:

Synonyms:3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Chemical Property of 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Technology Process of 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

There total 6 articles about 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262106-99-9
2-{4-chloro-1-[3-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

: 1262106-29-5
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: 2-{4-chloro-1-[3-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole; With sodium azide; In dimethyl sulfoxide; at 70 ℃; for 16h;

With triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 1h;

With acetic acid; at 120 ℃; for 1.5h;

Reference yield:

: 1262107-00-5
5-chloro-2-[3-(trifluoromethyl)phenyl]pentanoic acid

: 1262106-29-5
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diethyl cyanophosphonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h / 80 °C

3.1: sodium azide / dimethyl sulfoxide / 16 h / 70 °C

3.2: 1 h / 60 °C

3.3: 1.5 h / 120 °C

With tetrachloromethane; sodium azide; diethyl cyanophosphonate; triethylamine; triphenylphosphine; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1262107-01-6
N'-{5-chloro-2-[3-(trifluoromethyl)phenyl]pentanoyl}-3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide

: 1262106-29-5
3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h / 80 °C

2.1: sodium azide / dimethyl sulfoxide / 16 h / 70 °C

2.2: 1 h / 60 °C

2.3: 1.5 h / 120 °C

With tetrachloromethane; sodium azide; triphenylphosphine; In dimethyl sulfoxide; acetonitrile;