3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

Base Information

Chemical Name:3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea
CAS No.:1219722-73-2
Molecular Formula:C₂₂H₂₆N₄O₅
Molecular Weight:426.472
Hs Code.:

Synonyms:3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

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Chemical Property of 3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

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Technology Process of 3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

There total 8 articles about 3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1219722-73-2
3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: tin(II) chloride dihdyrate / ethyl acetate / 20 °C

3: sodium hydrogencarbonate / dichloromethane / 0 °C

4: dichloromethane / 0.5 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 95 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 5: |Suzuki Coupling;
DOI:10.1021/jm400062r

Reference yield:

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 1219729-18-6
C₁₉H₂₃BrN₂O₅

: 1219722-73-2
3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 95 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400062r

Reference yield:

: 70365-15-0
C₁₀H₁₃NO₂

: 1219722-73-2
3-(2-(2-hydroxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / 1 h / 0 - 20 °C

2: dichloromethane / 0.5 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 95 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1021/jm400062r