ICI 197067

Base Information

Chemical Name:ICI 197067
CAS No.:136328-64-8
Molecular Formula:C₁₈H₂₆Cl₂N₂O
Molecular Weight:357.323
Hs Code.:

Synonyms:ICI 197067

Suppliers and Price of ICI 197067

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ICI 197067

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Technology Process of ICI 197067

There total 3 articles about ICI 197067 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 156004-66-9
1-<(2S)-3-methyl-2-(methylamino)butyl>pyrrolidine

: 6831-55-6
2-(3,4-dichlorophenyl)acetyl chloride

: 136328-64-8
ICI 197067

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm00115a001

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 136328-64-8
ICI 197067

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide (DCCI) / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 20 deg C, 18 h

2: 67 percent / LAH / tetrahydrofuran / 16 h / 20 °C

3: 94 percent / CH₂Cl₂ / 0.5 h / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00115a001

Reference yield:

: 56414-68-7
benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate

: 136328-64-8
ICI 197067

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / LAH / tetrahydrofuran / 16 h / 20 °C

2: 94 percent / CH₂Cl₂ / 0.5 h / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00115a001