(S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

Base Information

Chemical Name:(S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid
CAS No.:124735-79-1
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:(S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

Chemical Property:

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Technology Process of (S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

There total 2 articles about (S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7622-21-1,93434-59-4,7622-22-2
(R)-benzyl mandelate

: 124735-79-1
(S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 1) -20 deg C, 2) warming to 10 deg C

2: 1) proton sponge, 2) H₂ / 2) 10 percent Pd/C / 1) CH₂Cl₂, r.t., 2) EtOH, 50 psi

With pyridine; Proton Sponge; hydrogen; palladium on activated charcoal; In dichloromethane;
DOI:10.1021/jm00124a002

Reference yield:

: 16874-17-2
L-phenylalanine tert-butyl ester

: 111437-25-3
benzyl (R)-(+)-3-phenyl-2-(trifluoromethylsulfonyloxy)propanoate

: 124735-79-1
(S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

Guidance literature:: With Proton Sponge; hydrogen; palladium on activated charcoal; Multistep reaction; 1) CH₂Cl₂, r.t., 2) EtOH, 50 psi;
DOI:10.1021/jm00124a002

Reference yield:

: 124735-79-1
(S)-2-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethylamino)-3-phenyl-propionic acid

: 124735-82-6
(S)-2-[(S)-1-(2-Carboxy-ethylcarbamoyl)-2-phenyl-ethylamino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DEC, hydroxybenzotriazole, N-methylmorpholine / dimethylformamide

2: H₂ / 10 percent Pd/C / ethanol / 2585.7 Torr

With 4-methyl-morpholine; diethylcarbamazine; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00124a002