(1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

Base Information

Chemical Name:(1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane
CAS No.:949139-45-1
Molecular Formula:C₂₃H₂₇NO₂
Molecular Weight:349.473
Hs Code.:

Synonyms:(1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

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Chemical Property of (1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

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Technology Process of (1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

There total 8 articles about (1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (1S,5S)-(+)-5-(3-methoxyphenyl)-9-oxo-2-azabicyclo[3.3.1]nonane

: 103-63-9
1-phenyl-2-bromoethane

: 949139-45-1
(1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 24h; Heating;
DOI:10.1021/jm061325e

Reference yield: 94.0%

: C₂₃H₂₇NO₂

: 949139-45-1
(1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 25 ℃;

Reference yield:

: 37786-58-6
3-cyano-1-(dimethylamino)-3-(m-methoxyphenyl)propane

: 949139-45-1
(1S,5S)-(-)-5-(3-methoxyphenyl)-9-oxo-2-phenylethyl-2-azabicyclo[3.3.1]nonane

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran

2.1: trifluoroacetic acid / water

3.1: bromine; acetic acid / water

4.1: ammonium hydroxide / water

5.1: bromocyane; potassium carbonate / 4 h / 20 °C / Reflux

5.2: 16 h / Reflux

6.1: potassium carbonate / acetonitrile

7.1: boron tribromide / dichloromethane / -78 - 25 °C

With bromocyane; bromine; boron tribromide; sodium hydride; potassium carbonate; ammonium hydroxide; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;