ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate

Base Information

• Chemical Name: ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate
• CAS No.: 609365-61-9
• Molecular Formula: C₁₅H₁₇NO₄
• Molecular Weight: 275.304
• Mol file: 609365-61-9.mol

Synonyms:ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate

Chemical Property of ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate

There total 3 articles about ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin (52726-86-0) + (1R,2S)-1-Chlorocarbonyl-2-vinyl-cyclopropanecarboxylic acid ethyl ester → ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate (609365-61-9)

Guidance literature:

N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin; (1R,2S)-1-Chlorocarbonyl-2-vinyl-cyclopropanecarboxylic acid ethyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 20h;

With sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/ma021678x

Reference yield:

2-vinylcyclopropane-1,1-dicarboxylic acid monoethyl ester (28465-22-7) → ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate (609365-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (COCl)2 / CH₂Cl₂ / 4 h / 40 °C

2.1: Et₃N / CH₂Cl₂ / 20 h / 20 °C

2.2: 7.57 g / NaHCO₃ / CH₂Cl₂

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1021/ma021678x

Reference yield:

4-amino-phenol (123-30-8) → ethyl 1-{[(4-hydroxyphenyl)amino]carbonyl}-2-vinylcyclopropanecarboxylate (609365-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / 2 h / Heating

2.1: Et₃N / CH₂Cl₂ / 20 h / 20 °C

2.2: 7.57 g / NaHCO₃ / CH₂Cl₂

With triethylamine; In dichloromethane;

DOI:10.1021/ma021678x

upstream raw materials:

N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin

2-vinylcyclopropane-1,1-dicarboxylic acid monoethyl ester

4-amino-phenol