Boc-D-serine

Base Information Edit

Chemical Name:Boc-D-serine
CAS No.:6368-20-3
Molecular Formula:C₈H₁₅NO₅
Molecular Weight:205.211
Hs Code.:29241990
European Community (EC) Number:613-313-8
DSSTox Substance ID:DTXSID10348465
Nikkaji Number:J265.557H
Wikidata:Q72450698
Mol file:6368-20-3.mol

Synonyms:Boc-D-serine;6368-20-3;Boc-D-Ser-OH;N-Boc-D-serine;N-(tert-Butoxycarbonyl)-D-serine;(tert-butoxycarbonyl)-D-serine;(2R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;Boc-L-Ser-OH;D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-;(2R)-2-[(tert-butoxycarbonyl)amino]-3-hydroxypropanoic acid;(R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid;(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxypropanoic acid;MFCD00063142;(R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid;boc-(D)-serine;Boc-D-Ser;(R)-N-Boc-serine;N-Boc-(D)-serine;(2R)-BOC-serine;(2R)-N-BOC-serine;Boc-D-serine monohydrate;N-t-butoxycarbonyl-D-serine;SCHEMBL47301;(2S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxypropanoic acid;N-t-butyloxycarbonyl-D-serine;N-tert-Butoxycarbonyl-D-serine;DTXSID10348465;BCP04714;FD3065;AKOS016842873;AM82210;CS-W002294;HY-W002294;AC-24071;AC-24072;Boc-D-Ser-OH, >=98.0% (TLC);DS-14371;(tert-Butoxycarbonyl)-D-serine monohydrate;B2258;EN300-96262;EC 444-670-6;J-300229;Q-101712;N-alpha-t-Butyloxycarbonyl-D-serine (Boc-D-Ser-OH);(r)-2-(tert-butoxycarbonylamino)-3-hydroxypropanoic acid;(r)-2-tert-butoxycarbonylamino-3-hydroxy-propionic acid

Suppliers and Price of Boc-D-serine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
BOC-D-Ser-OH
5g
$ 382.00

TRC
Boc-D-serine
10g
$ 375.00

TCI Chemical
N-(tert-Butoxycarbonyl)-D-serine >98.0%(HPLC)(T)
1g
$ 12.00

TCI Chemical
N-(tert-Butoxycarbonyl)-D-serine >98.0%(HPLC)(T)
5g
$ 33.00

Sigma-Aldrich
Boc-D-Ser-OH Novabiochem?
25 g
$ 401.00

Sigma-Aldrich
Boc-D-Ser-OH Novabiochem . CAS 6368-20-3, molar mass 205.21 g/mol., Novabiochem
8530960025
$ 387.00

Sigma-Aldrich
Boc-D-Ser-OH ≥98.0% (TLC)
5g
$ 133.00

Matrix Scientific
Butoxycarbonylamino)?-?3-?hydroxypropanoic acid; (R)?-?2-?(tert-? 97%
1g
$ 83.00

Matrix Scientific
Butoxycarbonylamino)?-?3-?hydroxypropanoic acid; (R)?-?2-?(tert-? 97%
10g
$ 479.00

Iris Biotech GmbH
Boc-D-Ser-OH
25 g
$ 303.75

Total 169 raw suppliers

Chemical Property of Boc-D-serine Edit

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:1.61E-07mmHg at 25°C
Melting Point:91-95 °C(lit.)
Refractive Index:1.4540 (estimate)
Boiling Point:385.1 °C at 760 mmHg
PKA:3.62±0.10(Predicted)
Flash Point:186.7 °C
PSA：95.86000
Density:1.24 g/cm³
LogP:0.34750
Storage Temp.:Store at RT.
Solubility.:DMSO (Slightly), Methanol (Slightly)
Water Solubility.:almost transparency
XLogP3:-0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:205.09502258
Heavy Atom Count:14
Complexity:220

Purity/Quality:

99% ^*data from raw suppliers

BOC-D-Ser-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CO)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CO)C(=O)O
Uses Boc-D-serine is D-serine (S270975) with amine protected from eletrophiles by tert-butyloxycarbonyl group in organic synthesis. Boc-D-serine can be used to synthesize acetamido-methoxypropionamides such as Desacetyl Desmethyl Lacosamide (D288325) which is a potent anticonvulsant.

Technology Process of Boc-D-serine

There total 7 articles about Boc-D-serine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 312-84-5,83245-15-2
D-Serine

: 24424-99-5
di-tert-butyl dicarbonate

: 3262-72-4,3850-40-6,6368-20-3,90582-28-8,84311-18-2
(R)-N-tert-butoxycarbonyl serine

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 0 - 25 ℃; for 2h;
DOI:10.1021/ja00097a072

Reference yield: 99.0%

: 312-84-5,83245-15-2
D-Serine

: 3262-72-4,3850-40-6,6368-20-3,90582-28-8,84311-18-2
(R)-N-tert-butoxycarbonyl serine

Guidance literature:: With di-tert-butyl dicarbonate; sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 7h;
DOI:10.1002/chem.201801868