1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

Base Information

Chemical Name:1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline
CAS No.:104156-43-6
Molecular Formula:C₂₁H₃₀FN₃O₄
Molecular Weight:407.485
Hs Code.:

Synonyms:1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

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Technology Process of 1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

There total 6 articles about 1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 104156-42-5
[2-(4-Fluoro-phenyl)-4-hydroxymethyl-1-methyl-2,5-dihydro-1H-pyrrol-3-yl]-methanol

: 1795-48-8
Isopropyl isocyanate

: 104156-43-6
1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

Guidance literature:: With dibutyltin diacetate; In dichloromethane; for 15h; Heating;
DOI:10.1021/jm00161a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 104156-43-6
1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) triphenylphosphine / 1.) benzene, reflux, 1.5 h, 2.) benzene, reflux, 1 h

2: CH₂Cl₂ / 15 h / 25 °C

3: CsF / 1,2-dimethoxy-ethane / 15 h / 25 °C

4: 22 percent / disobutylaluminum hydride (DIBAL) / toluene / 3 h / 25 °C

5: 45 percent / dibutyltin diacetate / CH₂Cl₂ / 15 h / Heating

With dibutyltin diacetate; diisobutylaluminium hydride; triphenylphosphine; cesium fluoride; In 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm00161a019

Reference yield:

: 104156-56-1
(E)-N-(4-fluorobenzylidene)methanamine

: 104156-43-6
1-methyl-2-(4-fluorophenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 20 h / 25 °C

2: CsF / 1,2-dimethoxy-ethane / 15 h / 25 °C

3: 22 percent / disobutylaluminum hydride (DIBAL) / toluene / 3 h / 25 °C

4: 45 percent / dibutyltin diacetate / CH₂Cl₂ / 15 h / Heating

With dibutyltin diacetate; diisobutylaluminium hydride; cesium fluoride; In 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm00161a019