Boc-D-phenylalanine

Base Information

Chemical Name:Boc-D-phenylalanine
CAS No.:18942-49-9
Molecular Formula:C14H19NO4
Molecular Weight:265.309
Hs Code.:29242990
DSSTox Substance ID:DTXSID50348469
Nikkaji Number:J814.363C
Wikidata:Q72450259
Mol file:18942-49-9.mol

Synonyms:Boc-D-Phe-OH;Boc-D-phenylalanine;18942-49-9;N-Boc-D-phenylalanine;N-(tert-Butoxycarbonyl)-D-phenylalanine;(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoic acid;d-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-;MFCD00063149;(R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANOIC ACID;BocDPheOH;Boc-D-PheOH;Boc-DPhe-OH;Boc-D-phenyl-alanine;N-Boc-D-Phe;Boc-(D)Phe-OH;BOC-D-PHE;(TERT-BUTOXYCARBONYL)-D-PHENYLALANINE;SCHEMBL606309;t-butoxycarbonyl-D-phenylalanine;DTXSID50348469;(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoic acid;tert-butyloxycarbonyl-d-phenylalanine;tert.-butoxycarbonyl-D-phenylalanine;N-(t-Butoxycarbonyl)-D-phenylalanine;AKOS015888245;AKOS015924106;AM82156;CS-W010128;HY-W009412;N-(tert-Butoxycarbonyl)phenylalanine #;N-tert-butyloxycarbonyl-D-phenylalanine;DS-13505;N-tert-butoxycarbonyl-beta-phenyl-D-alanine;B2989;N-alpha-tert-Butyloxycarbonyl-D-phenylalanine;EN300-35010;M03311;A813323;(R)-tert-butoxycarbonylamino-3-phenyl-propionic acid;J-300206;Q-101753;Boc-D-Phe-OH, >=99.0% (sum of enantiomers, TLC);(2R)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid;(2R)-2-tert-butoxycarbonylamino-3-phenylpropionic acid;Z285139170;2-(tert-butoxycarbonylamino)-3-phenyl-propanoate

Suppliers and Price of Boc-D-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Boc-D-Phenylalanine
100 g
$ 71.00

SynQuest Laboratories
Boc-D-Phenylalanine
25 g
$ 24.00

TCI Chemical
N-(tert-Butoxycarbonyl)-D-phenylalanine >98.0%(T)
5g
$ 14.00

TCI Chemical
N-(tert-Butoxycarbonyl)-D-phenylalanine >98.0%(T)
25g
$ 37.00

TRC
Boc-D-Phenylalanine
5g
$ 45.00

TRC
Boc-D-Phenylalanine
25g
$ 60.00

Usbiological
Boc-D-phenylalanine 99+%
5g
$ 163.00

Usbiological
Boc-D-Phe
500mg
$ 333.00

Usbiological
Boc-D-Phe
250mg
$ 193.00

Sigma-Aldrich
Boc-D-Phe-OH Novabiochem?
100 g
$ 94.50

Total 36 raw suppliers

Chemical Property of Boc-D-phenylalanine

Chemical Property:

Appearance/Colour:white fine crystalline powder
Vapor Pressure:4.88E-08mmHg at 25°C
Melting Point:78-87 °C
Refractive Index:-25 ° (C=1, EtOH)
Boiling Point:426.6 °C at 760 mmHg
PKA:3.88±0.10(Predicted)
Flash Point:211.8 °C
PSA：75.63000
Density:1.16 g/cm³
LogP:2.59790
Storage Temp.:2-8°C
Solubility.:DMSO, Ethanol, Methanol
Water Solubility.:insoluble
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:265.13140809
Heavy Atom Count:19
Complexity:316

Purity/Quality:

99% ^*data from raw suppliers

Boc-D-Phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CC1=CC=CC=C1)C(=O)O
Description BOC-D-Phenylalanine is the BOC (tert-butyloxycarbonyl) protected form of D-phenylalanine. It can be used in the synthesis of benzo[de][1,7] napthyridinones as PARP1 inhibitors. It is also an important reagent during the manufacturing of proline-containing, ?-turn mimetic cycle tetrapeptides.
Uses Boc-D-Phenylalanine is used in the synthesis of benzo[de][1,7]napthyridinones as PARP1 inhibitors. Also it is an important reagent in the preparation of proline-containing, β-turn mimetic cycle tetrap eptides. Boc-D-Phenylalanine is used in the synthesis of benzo[de][1,7]napthyridinones as PARP1 inhibitors. Also it is an important reagent in the preparation of proline-containing, β-turn mimetic cycle tetrapeptides.

Technology Process of Boc-D-phenylalanine

There total 49 articles about Boc-D-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 18942-49-9
Boc-D-Phe-OH

Guidance literature:: With sodium hydroxide; In water; for 6h;
DOI:10.1021/acs.jmedchem.0c01935

Reference yield: 97.0%

: 185509-03-9
{(R)-1-[((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 18942-49-9
Boc-D-Phe-OH

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; In water; tert-butyl alcohol; for 2.5h; Yields of byproduct given. Title compound not separated from byproducts; Heating;
DOI:10.1021/ja9624073