3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol

Base Information

• Chemical Name: 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol
• CAS No.: 644968-20-7
• Molecular Formula: C₁₆H₂₇NO₃
• Molecular Weight: 281.395
• Mol file: 644968-20-7.mol

Synonyms:3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol

Chemical Property of 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol

There total 4 articles about 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester (644968-17-2) → 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol (644968-20-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

DOI:10.1021/jo035072y

Reference yield:

3-benzyloxypropionitrile (6328-48-9) → 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol (644968-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / CoCl₂*6H₂O / methanol / 2 h / 20 °C

2: 2.95 g / methanol / 6 h / 20 °C

3: 97 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; cobalt(II) chloride; In tetrahydrofuran; methanol; 2: Michael addition;

DOI:10.1021/jo035072y

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 3-[(3-benzyloxy-propyl)-(3-hydroxy-propyl)-amino]-propan-1-ol (644968-20-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / NaOH / H₂O / 6 h / 20 °C

2: NaBH₄ / CoCl₂*6H₂O / methanol / 2 h / 20 °C

3: 2.95 g / methanol / 6 h / 20 °C

4: 97 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; cobalt(II) chloride; In tetrahydrofuran; methanol; water; 1: Michael addition / 3: Michael addition;

DOI:10.1021/jo035072y

upstream raw materials:

3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

3-benzyloxypropylamine

3-benzyloxypropionitrile

benzyl alcohol

Downstream raw materials:

3-[(3-{3-[(3-benzyloxy-propyl)-(3-{3-[bis-(2-tert-butoxycarbonyl-ethyl)-amino]-propoxy}-propyl)-amino]-propoxy}-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

3-(3-{(3-benzyloxy-propyl)-[3-(2-cyano-ethoxy)-propyl]-amino}-propoxy)-propionitrile