2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

Base Information

Chemical Name:2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole
CAS No.:1438285-41-6
Molecular Formula:C₂₆H₂₉N₃S
Molecular Weight:415.602
Hs Code.:

Synonyms:2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

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Chemical Property of 2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

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Technology Process of 2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

There total 12 articles about 2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1438285-40-5
C₂₉H₃₇N₃SSi

: 1438285-41-6
2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

Guidance literature:: With tetrabutyl ammonium fluoride; In 1,4-dioxane; at 23 ℃; Inert atmosphere; Heating;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-69-4
2-((1S,2R,3R,5R)-3-ethynyl-2-(3-hydroxypropyl)-3-(benzylamino)-5-methylcyclohexyl)acetonitrile

: 1438285-41-6
2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; 1H-imidazole / tetrachloromethane / 15 h / 77 °C / Inert atmosphere

2: dicarbonylcyclopentadienylcobalt / tetrahydrofuran / 140 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / 1,4-dioxane / 23 °C / Inert atmosphere; Heating

With 1H-imidazole; dicarbonylcyclopentadienylcobalt; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-71-8
2-((4aR,5R,7S,8aS)-1-benzyl-8a-ethynyl-7-methyldecahydroquinolin-5-yl)acetonitrile

: 1438285-41-6
2-((4aR,5S,10bR,12R)-1-benzyl-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8-yl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: dicarbonylcyclopentadienylcobalt / tetrahydrofuran / 140 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / 1,4-dioxane / 23 °C / Inert atmosphere; Heating

With dicarbonylcyclopentadienylcobalt; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo400695c