(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester
CAS No.:1026293-48-0
Molecular Formula:C₃₁H₄₆N₂O₈S
Molecular Weight:606.781
Hs Code.:

(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

Synonyms:(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

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Chemical Property of (2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

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Technology Process of (2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

There total 13 articles about (2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 404575-34-4
7-oxabicyclo<2.2.1>heptane tetrahydrofuranol

: 1026293-48-0
(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: EtMgBr / 0 - 25 °C

2: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

3: pyridine / 0 - 25 °C

4: n-Bu₄NF / tetrahydrofuran / 25 °C

5: 1.) Dess-Martin periodinane, 2.) K₂CO₃, NIS / 1.) CH₂Cl₂, 25 deg C, 2.) 25 deg C

6: K₂CO₃, MeOH / 25 °C

7: CrO₃, H₂SO₄ / acetone / 25 °C

8: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

9: (iPr)2NEt / CH₂Cl₂ / 0 °C

With pyridine; chromium(VI) oxide; methanol; N-iodo-succinimide; sulfuric acid; ethylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013

Reference yield:

: C₁₆H₂₇BrMgOSi

: 1026293-48-0
(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: EtMgBr / 0 - 25 °C

2: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

3: pyridine / 0 - 25 °C

4: n-Bu₄NF / tetrahydrofuran / 25 °C

5: 1.) Dess-Martin periodinane, 2.) K₂CO₃, NIS / 1.) CH₂Cl₂, 25 deg C, 2.) 25 deg C

6: K₂CO₃, MeOH / 25 °C

7: CrO₃, H₂SO₄ / acetone / 25 °C

8: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

9: (iPr)2NEt / CH₂Cl₂ / 0 °C

With pyridine; chromium(VI) oxide; methanol; N-iodo-succinimide; sulfuric acid; ethylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013

Reference yield:

: (2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

: 1026293-48-0
(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

2: pyridine / 0 - 25 °C

3: n-Bu₄NF / tetrahydrofuran / 25 °C

4: 1.) Dess-Martin periodinane, 2.) K₂CO₃, NIS / 1.) CH₂Cl₂, 25 deg C, 2.) 25 deg C

5: K₂CO₃, MeOH / 25 °C

6: CrO₃, H₂SO₄ / acetone / 25 °C

7: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

8: (iPr)2NEt / CH₂Cl₂ / 0 °C

With pyridine; chromium(VI) oxide; methanol; N-iodo-succinimide; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013