Imipenem hydrate

Base Information

• Chemical Name: Imipenem hydrate
• CAS No.: 74431-23-5
• Molecular Formula: C12H17N3O4S.H2O
• Molecular Weight: 317.36
• Hs Code.: 2941906000
• European Community (EC) Number: 680-398-6
• UNII: 71OTZ9ZE0A
• DSSTox Substance ID: DTXSID00873392
• Wikidata: Q27122763
• NCI Thesaurus Code: C570
• RXCUI: 5690
• Metabolomics Workbench ID: 57889
• ChEMBL ID: CHEMBL43708
• Mol file: 74431-23-5.mol

Synonyms:Anhydrous Imipenem;Anhydrous, Imipenem;Imipemide;Imipenem;Imipenem Anhydrous;Imipenem, Anhydrous;MK 0787;MK-0787;MK0787;N Formimidoylthienamycin;N-Formimidoylthienamycin

Chemical Property of Imipenem hydrate

Chemical Property:

• Appearance/Colour: off-white nonhygroscopic crytals
• Vapor Pressure: 3.11E-15mmHg at 25°C
• Melting Point: -116.3°C
• Boiling Point: 567.3 °C at 760 mmHg
• PKA: pKa 3.2/9.9(H2O,t = 25) (Uncertain)
• Flash Point: 296.9 °C
• PSA: 148.25000
• Density: 1.02g/mLat 25°C
• LogP: 0.18820
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: >5mg/mL
• Water Solubility.: Soluble in water at 5mg/ml
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 317.10454189
• Heavy Atom Count: 21
• Complexity: 491

Purity/Quality:

99% ^*data from raw suppliers

Imipenem monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F+,C
• Hazard Codes: F+,C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O
• Isomeric SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O
• Recent EU Clinical Trials: A Randomized, Active-Controlled Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter baumannii-calcoaceticus Complex
• Uses: antidiabetic Imipenem has a broad spectrum of antimicrobial action, which includes most clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for bacterial infections of the lower respiratory tract, infections of the urinary and sexual tracts, infections of bones, joints, skin, soft tissues, intraabdominal and gynecological infections, bacterial septicemia, and endocarditis. Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2- amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid (32.1.3.6), which inhibits metabolisms of imipenem in the kidneys. This combination of two compounds is also used in medicine under the name primaxin. An extremely broad-spectrum semi-synthetic antibiotic