(R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide

Base Information

• Chemical Name: (R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide
• CAS No.: 338751-83-0
• Molecular Formula: C₁₅H₂₂N₂O₅S
• Molecular Weight: 342.416
• Mol file: 338751-83-0.mol

Synonyms:(R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide

Chemical Property of (R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide

There total 1 articles about (R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isopropenyl acetate (108-22-5) + N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide → (R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide (338751-83-0)

Guidance literature:

With Pseudomonas cepaica PS-30; In tetrahydrofuran; at 40 - 45 ℃;

DOI:10.1021/jm0004289

Reference yield: 23.1%

(R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide (338751-83-0) → (R)-(+)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (338751-82-9)

Guidance literature:

With sodium dihydro-bis-(2-methoxyethoxy)aluminate; In tetrahydrofuran; toluene; at 20 ℃; for 20h;

DOI:10.1021/jm0004289

Reference yield:

(R)-(+)-N-[4-[4-(ethylamino)-4-oxo-1-acetoxybutyl]phenyl]methanesulfonamide (338751-83-0) → (R)-(+)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide (180918-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 23.1 percent / bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 20 h / 20 °C

2: NaHCO₃ / acetonitrile / 18 h / Heating

With sodium dihydro-bis-(2-methoxyethoxy)aluminate; sodium hydrogencarbonate; In tetrahydrofuran; toluene; acetonitrile;

DOI:10.1021/jm0004289

upstream raw materials:

Isopropenyl acetate

Downstream raw materials:

(R)-(+)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide

(R)-(+)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide