1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene

Base Information

• Chemical Name: 1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene
• CAS No.: 173846-89-4
• Molecular Formula: C₂₆H₂₃FN₂O₄S₂
• Molecular Weight: 510.61
• Mol file: 173846-89-4.mol

Synonyms:1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene

Chemical Property of 1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene

There total 1 articles about 1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.8%

2,6-bis(bromomethyl)-1-fluorobenzene (25006-86-4) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene (173846-89-4)

Guidance literature:

DOI:10.1002/ejoc.200300698

Reference yield: 50.1%

1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene (173846-89-4) + 4-chloro-2,6-bis(bromomethyl)-1-benzyloxybenzene (722546-74-9) → 9-benzyloxy-6-chloro-18-fluoro[3.3]metacyclophane-2,11-dione (722546-75-0)

Guidance literature:

1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene; 4-chloro-2,6-bis(bromomethyl)-1-benzyloxybenzene; With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; for 5h; Heating;

With hydrogenchloride; In dichloromethane; at 20 ℃; for 0.666667h; Further stages.;

DOI:10.1002/ejoc.200300698

Reference yield:

1-fluoro-2,6-bis[2-isocyano-2-(4-tolylsulfonyl)ethyl]benzene (173846-89-4) → 9-benzyloxy-6-chloro-18-fluoro[3.3]metacyclophane (722546-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaOH; nBu₄NI / CH₂Cl₂ / 5 h / Heating

1.2: 50.1 percent / HCl / CH₂Cl₂ / 0.67 h / 20 °C

2.1: 29 percent Spectr_. / hydrazine hydrate; KOH / bis-(2-hydroxy-ethyl) ether

With potassium hydroxide; sodium hydroxide; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; In dichloromethane; diethylene glycol; 2.1: Wolf-Kirschner reduction;

DOI:10.1002/ejoc.200300698

upstream raw materials:

2,6-bis(bromomethyl)-1-fluorobenzene

[(p-methylphenyl)sulfonylmethyl]isonitrile

Downstream raw materials:

9-benzyloxy-6-chloro-18-fluoro[3.3]metacyclophane-2,11-dione

9-benzyloxy-6-chloro-18-fluoro[3.3]metacyclophane