6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline

Base Information

• Chemical Name: 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline
• CAS No.: 380636-90-8
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.406
• Mol file: 380636-90-8.mol

Synonyms:6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline

Chemical Property of 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline

There total 7 articles about 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro[1,4]dioxino[2,3-g]isoquinolin-7-yl) 2,2,2-trifluoroacetate → 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline (380636-90-8)

Guidance literature:

With sodium hydroxide; In methanol; for 16h; Reflux;

DOI:10.1016/j.ejmech.2017.12.098

Reference yield: 96.0%

N-trifluoroacetyl-6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline → 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline (380636-90-8)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(01)00826-2

Reference yield: 55.0%

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-amine (10554-64-0) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 6-(3,4,5-trimethoxyphenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline (380636-90-8)

Guidance literature:

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-amine; 3,4,5-trimethoxy-benzaldehyde; In benzene; at 110 ℃; Inert atmosphere; Dean-Stark;

With phosphoric acid; In water; benzene; at 110 ℃; Inert atmosphere; Dean-Stark;

DOI:10.1016/j.ejmech.2017.12.098

upstream raw materials:

6-(3,4,5-trimethoxyphenyl)-2,3-dihyhydro[1,4]dioxino[2,3-g]isoquinoline

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-amine

3,4,5-trimethoxy-benzaldehyde

Downstream raw materials:

6-(3,4,5-trimethoxyphenyl)-2,3-dihyhydro[1,4]dioxino[2,3-g]isoquinoline