(R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: (R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester
• CAS No.: 57561-85-0
• Molecular Formula: C₃₀H₂₆N₄O₇S₃
• Molecular Weight: 650.757

Synonyms:(R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

Chemical Property of (R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

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Technology Process of (R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

There total 2 articles about (R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-nitrobenzyl(2S,4S,5R,6R)-3,3-dimethyl-7-oxo-6-phenoxyacetamido-1-aza-4-thiabicyclo<3.2.0>heptane-2-carboxylate 4-oxide (41625-65-4) + 2-Mercaptobenzothiazole (149-30-4,118090-09-8) → (R)-2-[(2R)-2r-benzothiazol-2-yldisulfanyl-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester (57561-85-0)

Guidance literature:

In toluene; Heating;

DOI:10.1016/S0040-4039(00)92502-4

Reference yield:

→ 4-nitrobenzyl 2-[(3R,4R)-4-[(benzothiazol-2-yl)dithio]-3-phenoxyacetamido-2-oxo-azetidin-1-yl]-3-methyl-3-butenoate (57561-85-0,61585-89-5,68000-27-1,84798-80-1)

Guidance literature:

Reference yield: 94.0%

4-nitrobenzyl 2-[(3R,4R)-4-[(benzothiazol-2-yl)dithio]-3-phenoxyacetamido-2-oxo-azetidin-1-yl]-3-methyl-3-butenoate (57561-85-0,61585-89-5,68000-27-1,84798-80-1) → p-nitrobenzyl (2R,3R)-2-(benzothiazol-2'-yldithio)-α-isopropylidene-4-oxo-3-phenoxyacetylaminoazetidine-1-acetate (64370-08-7)

Guidance literature:

With pyridine; for 5h; Ambient temperature;

upstream raw materials:

4-nitrobenzyl(2S,4S,5R,6R)-3,3-dimethyl-7-oxo-6-phenoxyacetamido-1-aza-4-thiabicyclo<3.2.0>heptane-2-carboxylate 4-oxide

2-Mercaptobenzothiazole

Downstream raw materials:

di(benzothiazol-2-yl)disulfide

4-nitrobenzyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 4-nitro-benzyl ester

2-Mercaptobenzothiazole

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