(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Base Information

Chemical Name:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide
CAS No.:1092477-62-7
Molecular Formula:C₂₃H₂₄F₆N₄O₃
Molecular Weight:518.459
Hs Code.:

Synonyms:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

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Chemical Property of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

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Technology Process of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

There total 5 articles about (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 886-35-1
3,5-bis(trifluoromethyl)phenylhydrazine

: 1092477-61-6
(+/-)-2,3-dihydro-1,4-benzodioxin-5-yl(4-methyl-1-piperazinyl)acetic acid

: 1092477-62-7
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: 3,5-bis(trifluoromethyl)phenylhydrazine; (+/-)-2,3-dihydro-1,4-benzodioxin-5-yl(4-methyl-1-piperazinyl)acetic acid; With benzotriazol-1-ol; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃;

With PS-Trisamine; PS-isocyanate; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 274910-20-2
2-(2,3-dihydro-1,4-benzodioxin-5-yl)acetic acid

: 1092477-62-7
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 85 °C

2.1: potassium carbonate / tetrahydrofuran / 0.08 h

2.2: 5 h / 20 °C

3.1: benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C

3.2: PS-isocyanate; PS-trisamine / 3 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; benzotriazol-1-ol; dibenzoyl peroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; dichloromethane;

Reference yield:

: 38871-41-9
2,3-dihydrobenzo-[b]-1,4-dioxine-5-carbonyl chloride

: 1092477-62-7
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 2 h / 0 - 20 °C

2.1: water; silver benzoate / 1,4-dioxane / 2 h / 70 °C

2.2: pH 2

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 85 °C

4.1: potassium carbonate / tetrahydrofuran / 0.08 h

4.2: 5 h / 20 °C

5.1: benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C

5.2: PS-isocyanate; PS-trisamine / 3 h / 20 °C

With N-Bromosuccinimide; water; silver benzoate; potassium carbonate; benzotriazol-1-ol; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; tetrachloromethane; dichloromethane; acetonitrile;