{(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

Base Information

Chemical Name:{(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate
CAS No.:1350734-44-9
Molecular Formula:C₁₈H₂₅NO₄S
Molecular Weight:351.467
Hs Code.:

Synonyms:{(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

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Chemical Property of {(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

Chemical Property:

Purity/Quality:

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Technology Process of {(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

There total 6 articles about {(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-91-9
thiobenzoic acid

: 1350734-49-4
tert-butyl ((1S,3S,6R)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate

: 1350734-43-8
{(1S,2S,4S)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl}-benzene-carbothioate

: 1350734-44-9
{(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

Guidance literature:: tetrabutyl-ammonium chloride; In toluene; at 15 - 45 ℃;

Reference yield:

: 5708-19-0
(1S)-3-cyclohexenecarboxylic acid

: 1350734-43-8
{(1S,2S,4S)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl}-benzene-carbothioate

: 1350734-44-9
{(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 60 °C / Reflux

1.2: 50 °C / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 40 °C / Cooling with ice

3.1: tetrabutyl-ammonium chloride / toluene / 15 - 45 °C

With diphenyl phosphoryl azide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrabutyl-ammonium chloride; In dichloromethane; toluene; 1.1: Curtius Rearrangement;

Reference yield:

: 67976-82-3
(1S)-3-cyclohexene-1-carboxylic acid (R)-(+)-α-methylbenzylamine salt

: 1350734-43-8
{(1S,2S,4S)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl}-benzene-carbothioate

: 1350734-44-9
{(1R,2R,5S)-5-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}benzene-carbothioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; tert-butyl methyl ether

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 60 °C / Reflux

2.2: 50 °C / Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 40 °C / Cooling with ice

4.1: tetrabutyl-ammonium chloride / toluene / 15 - 45 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrabutyl-ammonium chloride; In dichloromethane; tert-butyl methyl ether; water; toluene; 2.1: Curtius Rearrangement;