(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one
CAS No.:1593928-79-0
Molecular Formula:C₃₁H₂₆F₃NO₃
Molecular Weight:517.548
Hs Code.:

Synonyms:(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

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Chemical Property of (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

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Technology Process of (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

There total 4 articles about (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 192997-22-1
1?[3?(trifluoromethyl)benzyl]?1H?indole?3?carbaldehyde

: 1393921-62-4
1-(5-methoxy-2, 2-dimethyl-2H-chromen-8-yl)ethan-1-one

: 1593928-79-0
(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

Guidance literature:: With potassium hydroxide; In methanol; water; at 0 - 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.028

Reference yield:

: 1393921-61-3
1-(4-methoxy-2-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethanone

: 1593928-79-0
(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 12 h / 120 °C

2: potassium hydroxide / water; methanol / 48 h / 0 - 20 °C / Inert atmosphere

With pyridine; potassium hydroxide; In methanol; water; 1: |Claisen Rearrangement / 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmc.2014.02.028

Reference yield:

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 1593928-79-0
(E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(1-(3-(trifluoromethyl)benzyl)-1H-indol-3-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) chloride monohydrate / acetonitrile / 5 h / 0 °C

2: pyridine / 12 h / 120 °C

3: potassium hydroxide / water; methanol / 48 h / 0 - 20 °C / Inert atmosphere

With pyridine; copper(II) chloride monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hydroxide; In methanol; water; acetonitrile; 2: |Claisen Rearrangement / 3: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmc.2014.02.028