Technology Process of 2-{[2-({2-[(2-{[2-(phenylethynyl)phenyl]ethynyl}phenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline
There total 12 articles about 2-{[2-({2-[(2-{[2-(phenylethynyl)phenyl]ethynyl}phenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/jo2018119
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
6.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran; diethyl ether; hexane;
2.1: Sonogashira coupling / 4.1: Sonogashira coupling / 6.1: Sonogashira coupling;
DOI:10.1021/jo2018119
- Guidance literature:
-
Multi-step reaction with 5 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
5: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran;
1: Sonogashira coupling / 3: Sonogashira coupling / 5: Sonogashira coupling;
DOI:10.1021/jo2018119
