(S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide

Base Information

• Chemical Name: (S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide
• CAS No.: 1028184-28-2
• Molecular Formula: C₂₁H₁₆ClF₄NO₆S₃
• Molecular Weight: 591.94
• Mol file: 1028184-28-2.mol

Synonyms:(S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide

Chemical Property of (S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide

There total 4 articles about (S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{1-[4-(4-chlorobenzenesulfonyl)-phenyl]ethyl}-2,2,2-trifluoroacetamide (447460-00-6) → (S)-N-(1-(4-((4-chloro-2-((2-fluoro(13C6)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide (1028184-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: urea; hydrogen peroxide; trifluoroacetic anhydride / acetonitrile; ethyl acetate / 2.5 h / 20 °C

2: 86 percent / lithium hydroxide / acetonitrile; tetrahydrofuran; H₂O / 19 h

3: 72 percent / N-methylmorpholine / acetonitrile / 0.17 h

With 4-methyl-morpholine; lithium hydroxide; dihydrogen peroxide; urea; trifluoroacetic anhydride; In tetrahydrofuran; water; ethyl acetate; acetonitrile;

DOI:10.1002/jlcr.1183

Reference yield:

C3(13)C6H9FOS2 (1028184-51-1) → (S)-N-(1-(4-((4-chloro-2-((2-fluoro(13C6)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide (1028184-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: urea; hydrogen peroxide; trifluoroacetic anhydride / acetonitrile; ethyl acetate / 2.5 h / 20 °C

2: 86 percent / lithium hydroxide / acetonitrile; tetrahydrofuran; H₂O / 19 h

3: 72 percent / N-methylmorpholine / acetonitrile / 0.17 h

With 4-methyl-morpholine; lithium hydroxide; dihydrogen peroxide; urea; trifluoroacetic anhydride; In tetrahydrofuran; water; ethyl acetate; acetonitrile;

DOI:10.1002/jlcr.1183

Reference yield:

N-(1-{4-(4-chloro-2-(2-fluoro(13C)phenylsulfanyl)benzenesulfonyl)phenyl}ethyl)-2,2,2-trifluoroacetamide (1028184-21-5) → (S)-N-(1-(4-((4-chloro-2-((2-fluoro(13C6)phenyl)-sulfonyl)phenyl)sulfonyl)phenyl)-ethyl)trifluoromethanesulfonamide (1028184-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: urea; hydrogen peroxide; trifluoroacetic anhydride / acetonitrile; ethyl acetate / 2.5 h / 20 °C

2: 86 percent / lithium hydroxide / acetonitrile; tetrahydrofuran; H₂O / 19 h

3: 72 percent / N-methylmorpholine / acetonitrile / 0.17 h

With 4-methyl-morpholine; lithium hydroxide; dihydrogen peroxide; urea; trifluoroacetic anhydride; In tetrahydrofuran; water; ethyl acetate; acetonitrile;

DOI:10.1002/jlcr.1183

upstream raw materials:

N-{1-[4-(4-chlorobenzenesulfonyl)-phenyl]ethyl}-2,2,2-trifluoroacetamide

N-(1-{4-(4-chloro-2-(2-fluoro(¹³C)phenylsulfanyl)benzenesulfonyl)phenyl}ethyl)-2,2,2-trifluoroacetamide

(S)-N-(1-(4-((4-chloro-2-((2-fluoro(¹³C₆)phenyl)sulfoxyl)phenyl)sulfonyl)phenyl)-ethyl)-2,2,2-trifluoroacetamide

C₃⁽¹³⁾C₆H₉FOS₂