17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

Base Information

Chemical Name:17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol
CAS No.:212553-57-6
Molecular Formula:C₂₇H₃₀N₂O₅
Molecular Weight:462.546
Hs Code.:

Synonyms:17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

Suppliers and Price of 17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

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Technology Process of 17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

There total 3 articles about 17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 212553-53-2
N-(cyclopropylmethyl)-7α-(m-nitrophenyl)norhydrocodone

: 212553-57-6
17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 22h; Ambient temperature;
DOI:10.1021/jm9802214

Reference yield:

: 115799-23-0
bis-(3-nitro-phenyl)-iodonium ; iodide

: 212553-57-6
17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilazane / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, DMF, -45 deg C, 2 h

2: 99 percent / NaBH₄ / ethanol / 22 h / Ambient temperature

With sodium tetrahydroborate; lithium hexamethyldisilazane; In ethanol;
DOI:10.1021/jm9802214

Reference yield:

: 72706-73-1
17-(cyclopropylmethyl)-4,5α-epoxy-3-methoxy-6-oxo-morphinan

: 212553-57-6
17-(cyclopropylmethyl)-3-methoxy-4,5α-epoxy-7α-(m-nitrophenyl)morphinan-6α-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilazane / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, DMF, -45 deg C, 2 h

2: 99 percent / NaBH₄ / ethanol / 22 h / Ambient temperature

With sodium tetrahydroborate; lithium hexamethyldisilazane; In ethanol;
DOI:10.1021/jm9802214