2-(2-Aminoethyl)-1-methylpyrrolidine

Base Information

• Chemical Name: 2-(2-Aminoethyl)-1-methylpyrrolidine
• CAS No.: 51387-90-7
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 29339900
• European Community (EC) Number: 257-169-0
• NSC Number: 118052
• DSSTox Substance ID: DTXSID401291397
• Nikkaji Number: J236.383F
• Mol file: 51387-90-7.mol

Synonyms:2-(2-aminoethyl)-1-methylpyrrolidine

Chemical Property of 2-(2-Aminoethyl)-1-methylpyrrolidine

Chemical Property:

• Appearance/Colour: clear colorless to pale yellow liquid
• Vapor Pressure: 3.45mmHg at 25°C
• Refractive Index: n20/D 1.4684(lit.)
• Boiling Point: 152.729 °C at 760 mmHg
• PKA: 10.34±0.40(Predicted)
• Flash Point: 65 °C
• PSA: 29.26000
• Density: 0.909 g/cm³
• LogP: 1.06760
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Aminoethyl)-1-methylpyrrolidine >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1CCN
• Uses: 2-(2-Aminoethyl)-1-methylpyrrolidine is used as an electrochemiluminescence probe within microfluidic chip for ECL detection. 2-(2-Aminoethyl)-1-methylpyrrolidine is also used in chemical microarrays to identify ligands that bind pathogenic cells. 2-(2-Aminoethyl)-1-methylpyrrolidine was used in dual-cloud point extraction and tertiary amine labeling for the quantification of indole-3-acetic acid and indole-3-butyric acid.

Technology Process of 2-(2-Aminoethyl)-1-methylpyrrolidine

There total 2 articles about 2-(2-Aminoethyl)-1-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-isoindole-1,3-dione → 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE (51387-90-7,422545-96-8)

Guidance literature:

With diazene; In ethanol; for 3h;

DOI:10.1016/S0960-894X(03)00356-1

Reference yield:

→ 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE (51387-90-7,422545-96-8)

Guidance literature:

Reference yield: 98.0%

1,2-difluoro-4-iodo-benzene (64248-58-4) + 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE (51387-90-7,422545-96-8) → (3,4-difluoro-phenyl)-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-amine

Guidance literature:

With 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; copper(l) iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/ja063063b

Downstream raw materials:

3-benzyloxy-1-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-1H-pyridin-4-one

5-benzyloxy-2-methyl-1-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-1H-pyridin-4-one

Refernces

• 1、 Turner, Sean C.,Esbenshade, Timothy A.,Bennani, Youssef L.,Hancock, Arthur A.. "A new class of histamine H3-receptor antagonists: Synthesis and structure - Activity relationships of 7,8,9,10-Tetrahydro-6H-cyclohepta[b]quinolines". . p. 2131 - 2135. Retrieved 2007/10/03.