Technology Process of t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
There total 4 articles about t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 2,4-dioxopiperidine-1-carboxylate;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.0833333h;
m-nitrobenzhydroxamoyl chloride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 5h;
DOI:10.1002/chem.201001492
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ethyl acetate / 4 h / Reflux
2.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)
2.2: Combinatorial reaction / High throughput screening (HTS)
With
sodium hydride;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1021/co200200u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane
2.1: ethyl acetate / 4 h / Reflux
3.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)
3.2: Combinatorial reaction / High throughput screening (HTS)
With
dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/co200200u
