t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Base Information

Chemical Name:t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
CAS No.:1246303-75-2
Molecular Formula:C₁₇H₁₇N₃O₆
Molecular Weight:359.338
Hs Code.:

Synonyms:t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

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Chemical Property of t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

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Technology Process of t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

There total 4 articles about t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 845267-78-9
tert-butyl 2,4-dioxopiperidine-1-carboxylate

: 33512-94-6
m-nitrobenzhydroxamoyl chloride

: 1246303-75-2
t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: tert-butyl 2,4-dioxopiperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

m-nitrobenzhydroxamoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 5h;
DOI:10.1002/chem.201001492

Reference yield:

: C₁₀H₁₅NO₄

: 1246303-75-2
t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl acetate / 4 h / Reflux

2.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)

2.2: Combinatorial reaction / High throughput screening (HTS)

With sodium hydride; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/co200200u

Reference yield:

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: 1246303-75-2
t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2.1: ethyl acetate / 4 h / Reflux

3.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)

3.2: Combinatorial reaction / High throughput screening (HTS)

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/co200200u