(1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane

Base Information

• Chemical Name: (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane
• CAS No.: 197578-82-8
• Molecular Formula: C₂₆H₃₁NO₃
• Molecular Weight: 405.537

Synonyms:(1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane

Chemical Property of (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane

There total 5 articles about (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4R,5R,6R)-3-methyl-4-phenyl-5-(2-propenyl)-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-[1,2]-oxazine 2-oxide (197578-81-7) → (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.04,9]decane (197578-82-8)

Guidance literature:

With sodium hydrogencarbonate; In benzene; for 10h; Heating;

DOI:10.1021/jo9802170

Reference yield:

{(1S,2R)-2-[((E)-Penta-1,4-dienyl)oxy]-cyclohexyl}-benzene (197578-80-6) → (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.04,9]decane (197578-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₄ / CH₂Cl₂ / 0.17 h / -78 °C

2: 100 percent / NaHCO₃ / benzene / 10 h / Heating

With tin(IV) chloride; sodium hydrogencarbonate; In dichloromethane; benzene;

DOI:10.1021/jo9802170

Reference yield:

(1R,2S)-trans-2-phenylcyclohexanol (98919-68-7) → (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.04,9]decane (197578-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) KH, 3.) n-BuLi / 1.) THF, room temperature, 3 h, 2.) THF, -78 deg C; room temperature, 13 h, 3.) -78 deg C, -78 deg C to 0 deg C, 2.5 h; 0 deg C, 30 min, 4.) HMPA, -70 deg C to -50 deg C, 1 h; 0 deg C, 3 h

2: 85 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: SnCl₄ / CH₂Cl₂ / 0.17 h / -78 °C

4: 100 percent / NaHCO₃ / benzene / 10 h / Heating

With lithium aluminium tetrahydride; n-butyllithium; tin(IV) chloride; potassium hydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1021/jo9802170

upstream raw materials:

(4R,5R,6R)-3-methyl-4-phenyl-5-(2-propenyl)-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-[1,2]-oxazine 2-oxide

(1R,2S)-trans-2-phenylcyclohexanol

{(1S,2R)-2-[((E)-Penta-1,4-dienyl)oxy]-cyclohexyl}-benzene

1-[(1R,2S)-(2-phenylcyclohexyl)oxy]pent-4-en-1-yne

Downstream raw materials:

(1R,2S)-trans-2-phenylcyclohexanol

((1R,2R,3R,4S)-3-Amino-4-hydroxymethyl-3-methyl-2-phenyl-cyclopentyl)-methanol

1-[(1R,2S)-(2-phenylcyclohexyl)oxy]pent-4-en-1-yne

{(1S,2R)-2-[((E)-Penta-1,4-dienyl)oxy]-cyclohexyl}-benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 197578-82-8 (1S,6R,7R,8R,9R)-9-methyl-8-phenyl-6-[(1R,2S)-(2-phenylcyclohexyl)oxy]-4-aza-3,5-dioxatricyclo[5.2.1.0^4,9]decane

Send

Send

Metric Ton KG G Pound L ML

Send

Send