Technology Process of Diethyl 8-Deaza-10-thiafolic Acid
There total 8 articles about Diethyl 8-Deaza-10-thiafolic Acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 83 percent / m-Chloroperoxybenzoic acid / acetic acid / 3 h / Heating
2: 85 percent / acetic acid / 0.5 h / Heating
3: 62 percent / POCl3, (C2H5)3N / 8 h / Heating
4: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
5: 81 percent / 1 N NaOH / 10 h / Heating
6: PBr3 / tetrahydrofuran / 12 h
7: 1.) NaBH4 / 1.) ethanol, 2.) dimethylacetamide, room temperature, 6 h
With
sodium hydroxide; sodium tetrahydroborate; ammonia; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
tetrahydrofuran; acetic acid;
DOI:10.1021/jo00322a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: 81 percent / 1 N NaOH / 10 h / Heating
3: PBr3 / tetrahydrofuran / 12 h
4: 1.) NaBH4 / 1.) ethanol, 2.) dimethylacetamide, room temperature, 6 h
With
sodium hydroxide; sodium tetrahydroborate; ammonia; phosphorus tribromide;
In
tetrahydrofuran;
DOI:10.1021/jo00322a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / acetic acid / 0.5 h / Heating
2: 62 percent / POCl3, (C2H5)3N / 8 h / Heating
3: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
4: 81 percent / 1 N NaOH / 10 h / Heating
5: PBr3 / tetrahydrofuran / 12 h
6: 1.) NaBH4 / 1.) ethanol, 2.) dimethylacetamide, room temperature, 6 h
With
sodium hydroxide; sodium tetrahydroborate; ammonia; phosphorus tribromide; triethylamine; trichlorophosphate;
In
tetrahydrofuran; acetic acid;
DOI:10.1021/jo00322a004
