N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Base Information

Chemical Name:N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide
CAS No.:200400-57-3
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

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Chemical Property of N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Chemical Property:

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Technology Process of N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

There total 11 articles about N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16728-66-8
4-phenoxybutylamine

: 200400-57-3
N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 13 percent / H₂ / 5 percent Rh/C / ethanol / 24 h / 60 °C / 3102.89 Torr

2: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

3: TFA / CH₂Cl₂ / 0 - 20 °C

4: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

5: PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

6: NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; nickel(IV) oxide; 4 A molecular sieve; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; Rh on carbon; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm980173n

Reference yield:

: 200400-49-3
(S)-2-[4-(Pyridine-3-carbonyl)-phenyl]-4,5-dihydro-oxazole-4-carboxylic acid (4-cyclohexyloxy-butyl)-amide

: 200400-57-3
N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: With nickel(IV) oxide; 4 A molecular sieve; In 1,4-dioxane; benzene; for 4h; Yield given; Heating;
DOI:10.1021/jm980173n

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 200400-57-3
N-<4-(cyclohexyloxy)butyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) Et₂O, hexane, -78 deg C, 25 min, 2.) Et₂O, hexane, a) -78 deg C, 2 h, b) RT, 2 h

2: 81 percent / MnO₂ / tetrahydrofuran / 17 h / 70 °C

3: 1.0N aq. NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

4: HOBT, NMM, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 6.5 h / 0 - 20 °C

5: PPh₃, i-Pr₂NEt / acetonitrile; CCl₄ / 16 h / Ambient temperature

6: NiO₂, 4 Angstroem molecular sieves / benzene; dioxane / 4 h / Heating

With 4-methyl-morpholine; manganese(IV) oxide; nickel(IV) oxide; sodium hydroxide; n-butyllithium; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm980173n