3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

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Chemical Name:3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione
CAS No.:642471-92-9
Molecular Formula:C₂₉H₃₀N₂O₇S
Molecular Weight:550.632
Hs Code.:

Synonyms:3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

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Chemical Property of 3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

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Technology Process of 3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

There total 10 articles about 3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 368427-26-3
3-amino-3-(ethoxycarbonyl)-2,3-dihydrothieno[2,3-b]naphtho-4,9-dione

: 642471-92-9
3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(03)00310-9

Reference yield:

: 130-15-4
[1,4]naphthoquinone

: 642471-92-9
3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ag₂CO₃; DBU / acetonitrile / 12 h / 20 °C

1.2: HCl / H₂O; CHCl₃ / 1 h

2.1: 55 percent / HBTU; 1-hydroxybenzotriazole; diisopropylethylamine / tetrahydrofuran; dimethylformamide / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; silver carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1.1: Diels-Alder cycloaddition;
DOI:10.1016/S0968-0896(03)00310-9

Reference yield:

: 189228-43-1
(2RS,4R)-2-phenylthiazolidine-4-carboxylic acid ethyl ester

: 642471-92-9
3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ag₂CO₃; DBU / acetonitrile / 12 h / 20 °C

1.2: HCl / H₂O; CHCl₃ / 1 h

2.1: 55 percent / HBTU; 1-hydroxybenzotriazole; diisopropylethylamine / tetrahydrofuran; dimethylformamide / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; silver carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1.1: Diels-Alder cycloaddition;
DOI:10.1016/S0968-0896(03)00310-9