N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

Base Information

Chemical Name:N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide
CAS No.:1201659-65-5
Molecular Formula:C₂₇H₁₈ClF₃N₆O₂
Molecular Weight:550.927
Hs Code.:

Synonyms:N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

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Chemical Property of N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

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Technology Process of N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

There total 7 articles about N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1201659-62-2
N-(7-(4-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1201659-65-5
N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/j.bmcl.2009.10.051

Reference yield:

: 74895-37-7
2-Cyan-4,4-diethoxybuttersaeurenitril

: 1201659-65-5
N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium tert-butylate / ethanol / 0 °C / Reflux

2: hydrogenchloride / water / 1.17 h / 50 °C

3: Raney-Nickel / water / 4 h / Reflux

4: pyridine / 50 °C

5: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

6: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 2585.81 Torr

7: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; copper(l) iodide; palladium on activated charcoal; potassium tert-butylate; hydrogen; potassium carbonate; L-proline; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;
DOI:10.1248/cpb.c13-00249

Reference yield:

: 4,6-diamino-5-(2,2-diethoxyethyl)pyrimidine-2-thiol potassium salt

: 1201659-65-5
N-{{7-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / water / 1.17 h / 50 °C

2: Raney-Nickel / water / 4 h / Reflux

3: pyridine / 50 °C

4: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

5: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 2585.81 Torr

6: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; L-proline; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1248/cpb.c13-00249