N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester
• CAS No.: 674790-23-9
• Molecular Formula: C₂₆H₃₇N₃O₄
• Molecular Weight: 455.597

Synonyms:N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester

Chemical Property of N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester

Chemical Property:

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Technology Process of N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester

There total 3 articles about N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N-benzylhydrazine hydrochloride (1073-62-7,20570-96-1) + tert-butyl (S)-2-tert-butoxycarbonylamino-4-hydroxy-4-(2-oxocyclohexylidene-1-yl)butanoate → N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester (674790-23-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; for 4h;

DOI:10.1016/j.tetlet.2003.11.133

Reference yield:

1-(1-Cyclohexen-1-yl)pyrrolidine (1125-99-1) → N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester (674790-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / diisopropylcarbodiimide; DMPA / CH₂Cl₂ / 4 h

2: 51 percent / DIEA / ethanol / 4 h

With 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1016/j.tetlet.2003.11.133

Reference yield:

N-tert-butoxycarbonyl aspartic acid tert-butyl ester (34582-32-6) → N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester (674790-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / diisopropylcarbodiimide; DMPA / CH₂Cl₂ / 4 h

2: 51 percent / DIEA / ethanol / 4 h

With 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1016/j.tetlet.2003.11.133

upstream raw materials:

N-benzylhydrazine hydrochloride

1-(1-Cyclohexen-1-yl)pyrrolidine

N-tert-butoxycarbonyl aspartic acid tert-butyl ester

Downstream raw materials:

2-amino-3-(2-benzyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-propionic acid

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