6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol

Base Information

• Chemical Name: 6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol
• CAS No.: 1334173-36-2
• Molecular Formula: C₁₉H₁₇ClN₄O
• Molecular Weight: 352.823
• Mol file: 1334173-36-2.mol

Synonyms:6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol

Chemical Property of 6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol

There total 1 articles about 6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 1-(4-chlorobenzyl)-4-oxopiperidine-3-carboxylate (1225491-24-6) + pyridine-2-carboxamidine hydrochloride (51285-26-8,61097-49-2) → 6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (1334173-36-2)

Guidance literature:

With sodium methylate; In ethanol; at 80 ℃; for 2.5h;

DOI:10.1021/acs.jmedchem.5b00771

Reference yield: 100.0%

6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (1334173-36-2) → 4-chloro-6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:

With trichlorophosphate; In toluene; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.5b00771

Reference yield:

6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (1334173-36-2) → N-{1-[6-(4-chlorobenzyl)-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]pyrrolidin-3-yl}-N-ethylacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / toluene / 2 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 90 °C / Sealed tube

With triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.jmedchem.5b00771

upstream raw materials:

methyl 1-(4-chlorobenzyl)-4-oxopiperidine-3-carboxylate

pyridine-2-carboxamidine hydrochloride