1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Name:1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
CAS No.:1425937-19-4
Molecular Formula:C₂₂H₁₆F₃N₅O₂
Molecular Weight:439.397
Hs Code.:

Synonyms:1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Property of 1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Technology Process of 1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 5 articles about 1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425937-18-3
5-(benzyloxy)-1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 1425937-19-4
1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 10 - 35 ℃; for 2h;

Reference yield:

: 75329-65-6
1-(benzyloxy)-2,4-pentanedione

: 1425937-19-4
1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: N,N-dimethyl acetamide / 2 h / 80 °C

2.2: 0 - 35 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 48 h / 10 - 35 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h / 10 - 35 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; sodium nitrite; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; ethyl acetate;

Reference yield:

: 1425937-16-1
1-(benzyloxy)-3-[(2-fluoro-4-iodophenyl)hydrazono]pentane-2,4-dione

: 1425937-19-4
1-[4-(3,3-difluoroazetidin-1-yl)-2-fluorophenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl acetamide / 2 h / 80 °C

1.2: 0 - 35 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 48 h / 10 - 35 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h / 10 - 35 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; ethyl acetate;