2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine

Base Information

• Chemical Name: 2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine
• CAS No.: 889673-70-5
• Molecular Formula: C₁₉H₂₁ClN₄O
• Molecular Weight: 356.855
• Mol file: 889673-70-5.mol

Synonyms:2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine

Chemical Property of 2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine

There total 2 articles about 2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-phenyl-6-chloro-8-propyl-9H-purine (889673-66-9) → 2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine (889673-70-5)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran;

DOI:10.1021/jm050640i

Reference yield:

6-chloro-2-phenylpyrimidine-4,5-diamine (424830-76-2) → 2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine (889673-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂

1.2: 51 percent / aq. NaOH

2.1: 67 percent / pTSA / tetrahydrofuran

With pyridine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm050640i

Reference yield: 53.0%

2-phenyl-6-chloro-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine (889673-70-5) + phenylboronic acid (98-80-6) → 2,6-diphenyl-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine (889673-72-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 150 ℃; for 0.333333h; microwave irradiation;

DOI:10.1021/jm050640i

upstream raw materials:

3,4-dihydro-2H-pyran

2-phenyl-6-chloro-8-propyl-9H-purine

6-chloro-2-phenylpyrimidine-4,5-diamine

Downstream raw materials:

2,6-diphenyl-8-propyl-9-(tetrahydropyran-2-yl)-9H-purine